Frontline Flea & Tick Spot Treatment for Small Dogs 5–22 lbs (Orange) — 6-Pack, Waterproof Monthly Protection

FRONTLINE Plus for Small Dogs is a monthly, waterproof topical that kills fleas, flea eggs, flea larvae, chewing lice and ticks to help stop infestations. FRONTLINE Plus combines two active ingredients—fipronil and (S)-methoprene—into a single, easy-to-apply spot treatment designed for dogs weighing 5 to 22 pounds. Applied between the shoulder blades, the formula disperses through the skin’s natural oils and maintains activity for 30 days, even after swimming or bathing. This six-dose pack offers a convenient supply for half a year of routine protection when used monthly.

How quickly will FRONTLINE Plus start working on my small dog?

The treatment begins killing adult fleas shortly after application and continues acting against flea eggs and larvae to interrupt the life cycle. While individual results vary, many pet owners observe reductions in flea activity within hours and ongoing control with monthly reapplication.

• Begins targeting adult fleas soon after application
• Continues to affect flea eggs and larvae to prevent re-infestation
• One application provides up to 30 days of continuous protection

Is FRONTLINE Plus safe for puppies and small breeds?

FRONTLINE Plus for Dogs is formulated for use on puppies eight weeks and older weighing at least 5 pounds. Always follow label directions for correct dosage and application location to reduce the chance of irritation or accidental ingestion.

• Approved for puppies 8+ weeks and 5+ pounds
• Use one tube per dog per month according to weight range
• Apply to a single spot on the skin to minimize surface contact

Will the treatment stay effective if my dog swims or is bathed?

The active ingredients deposit in the skin’s sebaceous glands, which act as a reservoir and continuously release the treatment over the month. This delivery helps the formula remain effective even after normal swimming or bathing, though heavy or frequent shampooing can reduce longevity.

• Waterproof once absorbed into the skin’s oils
• Treatment is replenished from sebaceous gland reservoirs
• Limit frequent medicated baths to preserve month-long protection

How should I use FRONTLINE Plus to get the best results?

Apply the full tube directly to the skin at a single spot between the dog’s shoulder blades once every 30 days. Treat every dog and cat in the household according to their weight-specific product to prevent cross-infestation and break the flea life cycle.

• Part the fur and place tube tip against skin, not coat
• Empty entire tube at one spot to ensure proper dosing
• Treat all household pets monthly for effective control

Who is this for? FRONTLINE Plus for Small Dogs is intended for pet owners who want a reliable, once-monthly topical to protect companion dogs weighing 5–22 pounds from fleas, flea eggs, flea larvae, chewing lice, and ticks. It’s especially suitable for households seeking a waterproof option that integrates with regular activity like swimming, for caretakers of puppies eight weeks and older, and for anyone who prefers a six-dose pack for consistent monthly coverage. As with any veterinary product, consult your veterinarian if your dog is pregnant, nursing, ill, or on other medications before starting a new flea-and-tick regimen.

Ingredients

Active Ingredient: fipronil 9.8%, (S)-methoprene) 8.8%Inert Ingredients: 81.4%

FAQ

Q: How often should I apply FRONTLINE Plus for small dogs?

A: Apply one full tube once every 30 days. Treat all household pets monthly for best flea and tick control.

Q: Can I use FRONTLINE Plus after my dog swims?

A: Yes. The formula is waterproof once absorbed into the skin’s oils, but avoid frequent medicated baths that may reduce effectiveness.