Frontline flea and tick treatment for dogs Large (45–88 lb) 6 doses — waterproof monthly protection

FRONTLINE Plus for Dogs (Large, 45–88 lb) is a monthly topical treatment that kills adult fleas, flea eggs, flea larvae, ticks and chewing lice while helping prevent new infestations for up to 30 days per dose.

Protecting a large dog from fleas and ticks is easier with a waterproof, veterinarian-trusted topical that spreads through the skin’s oil and keeps working even after bathing. FRONTLINE Plus combines fipronil and (S)-methoprene in a single-dose applicator designed for dogs weighing 45 to 88 pounds. Each tube treats the dog at a single application point, where the active ingredients deposit in the sebaceous glands to provide continuous coverage for roughly one month.

How quickly does FRONTLINE Plus start working?

FRONTLINE Plus begins killing adult fleas soon after application and interrupts the flea life cycle by targeting eggs and larvae. Many pet owners notice reduction in biting and visible fleas within 24–48 hours, while the insect growth regulator helps prevent future generations from developing.

• Starts acting on live adult fleas soon after application
• (S)-methoprene prevents eggs and larvae from maturing
• One application protects for approximately 30 days
• Designed to deposit in skin oils for continuous release

Is FRONTLINE Plus safe for my dog and waterproof?

FRONTLINE Plus is formulated for use on dogs and puppies meeting the age and weight requirements listed on the label. The treatment becomes waterproof about 24 hours after application, allowing normal bathing and light swimming without losing effectiveness.

• Approved for use on puppies eight weeks and older (weight-specific guidance applies)
• Waterproof 24 hours after application for routine exposure to water
• Applied topically at a single site to coat the whole body via sebaceous glands
• Follow label instructions for safe dosing and household use

How should I use FRONTLINE Plus to control fleas and ticks in my home?

Treat every dog and cat in the household on schedule to break the flea life cycle and reduce reinfestation risk. Monthly dosing, combined with cleaning bedding and vacuuming, helps remove eggs and larvae from the environment so pets remain protected.

• Apply once every 30 days for ongoing protection
• Treat all pets in the home with species-appropriate FRONTLINE products
• Vacuum and wash pet bedding regularly to reduce environmental stages
• Use consistent monthly dosing to prevent establishment of new infestations

What does a six-dose pack include and why subscribe?

This listing supplies six single-dose applicators formulated for dogs weighing 45–88 pounds, providing half a year of monthly protection when used as directed. Subscribing ensures doses arrive before you run out and helps maintain continuous coverage without interruption.

• Six individual topical applicators for six months of protection
• Convenient monthly schedule: one tube per month per dog
• Subscription options available to ensure uninterrupted treatment
• Ideal for multi-dog households using the same dose range

Who is this for? FRONTLINE Plus for Dogs (Large, 45–88 lb) is intended for dog owners who want a clinically recognized, easy-to-apply monthly topical that targets adult fleas, eggs and larvae as well as ticks and chewing lice. It’s well suited for families with active dogs, those living in tick-prone areas, or households aiming to stop a current flea problem and prevent future infestations. Always read and follow product labeling for age, weight, and safety instructions before use.

Ingredients

Fipronil (9.8%)|(S)-Methoprene (8.8%)